Get Computational Strategies Towards Improved Protein Function PDF

By MVK Karthik, Pratyoosh Shukla

This short stories at the interaction of an amino-acid mutation in the direction of substrate which may result in greater results on mutant. those results must be given attention within the engineering approaches of protein balance and additional exploration of such studying are required to supply novel indication for number of an enzymes. There are only a few reviews displaying such reliable, power effective version in the direction of enhanced protein functionality prediction screening in-silico constitution established mutagenesis of xylanases from Thermomyces lanuginosus​

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Additional info for Computational Strategies Towards Improved Protein Function Prophecy of Xylanases from Thermomyces lanuginosus

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Further plots were generated detailing the value of the error function versus position of a 9-residue sliding window and were designed from highly refined structures. 1 docking program was used for protein molecules docking calculations (Ritchie and Venkatraman 2010). In these calculations, each molecule corresponds to 3D parametric functions describing surface shape, electrostatic charge, and potential distributions. In this study, we used substrates viz. 1) and 1YNA wild type where amino acids involved in interactions were identified.

V. K. Karthik and P. 1007/978-1-4614-4723-8_5, Ó The Author(s) 2012 43 44 5 Conclusion However, Al Balaa et al. (2009), Galperin and Koonin (2000) described site-directed mutagenesis in xylanase XYL1p from Scytalidium acidophilum. One noteworthy contribution on mutant of family 11 xylanase from Neocallimastix patriciarum specified the thermostability and substrate selection. e. Thermomyces lanuginosus) by means of pioneering computational strategies using some state-of-theart tools viz. ConSurf, InterProScan, and GROMOS 43B1.

References 25 Pellegrini M, Marcotte E, Thompson M, Eisenberg D, Yeates T (1999) Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Proc Natl Acad SciU S A 96(8):4285–4288 Phizicky EM, Fields S (1995) Protein–protein interactions: methods for detection and analysis. Microbiol Rev 59(1):94–123 Porollo A, Meller J (2007) Prediction-based fingerprints of protein–protein interactions. Proteins 66(3):630–645 Rajamani D, Thiel S, Vajda S, Camacho C (2004) Anchor residues in protein-protein interactions.

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