By Michael T. McMahon, Assaf A. Gilad, Jeff W.M. Bulte, Peter C.M. van Zijl
Chemical trade saturation move (CEST) imaging is a robust magnetic resonance imaging (MRI) procedure with special distinction gains. This expertise permits the amplified detection of nM to mM concentrations of small molecules and macromolecules (including these concerned about biologic pathways) via selective radio frequency labeling of speedily changing protons current at the molecules of curiosity. simply because this labeling is frequency based, CEST brokers have benefits over the extra proven water relaxation–based distinction brokers, making them extra just like optical imaging brokers and permitting the detection of a number of brokers independently inside of an anatomical quarter for a variety of molecular imaging purposes. The fast growth that CEST imaging has visible during the last 15 years considering the fact that its unique discovery in 2000 had created a necessity for a graduate-level instruction manual describing all facets of preclinical, translational, and scientific CEST imaging, and this can be the 1st devoted textbook overlaying all of them.
The ebook contains 19 chapters that conceal the basic rules of saturation move, the main gains of CEST brokers permitting creation of imaging distinction, and the sensible features of photograph acquisition and imaging post-processing schemes adapted to the explicit program. during this publication, the leaders who constructed CEST imaging on the 5 key websites current a special, illustrated, historic viewpoint from the preliminary saturation move nuclear magnetic resonance (NMR) experiments played within the Nineteen Sixties in Stockholm, Sweden, defined via Sture Forsén, to the paintings performed on integrating the fundamental ideas of CEST into imaging within the usa and Italy, lined via Robert Balaban, Dean Sherry, Silvio Aime, and Peter van Zijl. The editors, Drs. Michael T. McMahon, Assaf A. Gilad, Jeff W. M. Bulte, and Peter C. M. van Zijl, are pioneers constructing this box on the Johns Hopkins collage tuition of medication and the Kennedy Krieger Institute.