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Extra info for Brilliant 4: Pupil's Book (Children's courses)
N. Eng. J. , 322, 1775–1780. , Cervoni, A. and Levi, G. (1979) Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine. J. Pharmacol. Exp. , 208, 195–202. Site-selective action 25 Rezvani, A. , Overstreet, D. H. and Leef, Y. W. (1995) Attenuation of alcohol intake by three strains of alcohol-preferring rats. Pharmacol. Biochem. , 52, 615–620. , Kohn, J. and White, T. (1992) Patterns of fos expression suggest similar mechanisms of action for the excitotoxins domoic acid and kainic acid.
2 Examples of neurotoxicants with known neurochemical mechanisms Site of action 1. Neurotoxicants acting on ionic balance: A. Inhibit sodium entry B. Block closing of sodium channel C. Increase permeability to sodium D. Increase intracellular calcium 2. Synaptic neurotoxicants 3. Uptake blockers 4. Metabolic poisons 5. Hyperactivation of receptors 6. Blocks transmitter release 7. Inhibition of transmitter degradation 8. Blocks axonal transport 9. Disrupt microtubes 10. Disrupts lipid synthesis Examples Tetrodotoxin p,p’-DDT, Pyrethroids Batrachotoxin Chlordecone MPTP Hemicholinium Cyanide Domoic acid Botulinum toxin Organophosphates and Carbamates Acrylamide Colchicine Tellurium From Bondy (1982), Mailman (1987), Costa (1988), ECETOC (1992), US EPA (1994).
Siegel, B. W. Agranoff, R. Albers and P. B. ), Basic Neurochemistry, Raven Press, New York, pp. 75–95. Krinke, G. J. (1989) Neuropathologic screening in rodent and other species. J. Amer. Coll. Toxicol. 8: 141–155. Mailman, R. B. (1987) Mechanisms of CNS injury in behavioral dysfunction. Neurotoxicol. Teratol. 9: 417–426. McGonigle, P. and Molinoff, P. B. (1994) Receptors and signal transduction: Classification and quantification. In G. Siegel, B. W. Agranoff, R. Albers and P. B. ), Basic Neurochemistry, Raven Press, New York, pp.