Download e-book for iPad: Biotechnology, Genomics and Bioinformatics by Christoph W. Sensen

By Christoph W. Sensen

Genomics is a brand new self-discipline that's revolutionizing the best way organic and scientific learn is completed. The human genome is nearly thoroughly sequenced, as a way to aid to speed up examine and improvement in Genomics much more. The chapters during this booklet attempt to trap the quickly evolving box. Overviews of nucleic acid applied sciences, proteomics and bioinformatics are by way of chapters on purposes, together with human well-being, agriculture and comparative genomics. The ebook additionally comprises chapters on felony and moral problems with Genomics, an issue that's turning into an increasing number of very important.

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Extra resources for Biotechnology, Genomics and Bioinformatics

Sample text

2: 4,037, chr. 4: 3,744 annotat- ed genes), whereas the mitochondrial and the plastid genomes carry only 57 and 78 genes on 366,924 and 154,478 bp of DNA, respectively. Therefore, most of the organellar proteins have to be encoded in the nucleus and are targeted to their final destinations via N-terminal transit peptides. , 2000). , 1999), even though lateral gene transfer from the endosymbiotic organelle to the nucleus has been assumed to be the main source of organellar proteins. These data indicate that either the large evolutionary distance between plants and cyanobacteria prevents the recognition of orthologs and/or that many proteins from other sources in the eukaryotic cell have acquired plastid transit peptides as suggested earlier based on Calvin cycle enzymes (MARTINand SCHNARRENBERGER, 1997).

The analysis of chromosomes I11 and XI revealed an almost regular periodicity of the GC content, with a succession of GC-rich and GC-poor segments of 50 kb each, a further interesting observation being that the compositional periodicity correlated with local gene density. Profiles obtained from similar analyses of chromosomes I1 and VIII again showed these phenomena, albeit with less pronounced regularity. Other chromosomes also show compositional variation of similar range along their arms, with pericentromeric and subtelomeric regions being AT-rich, though spacing between GCrich peaks is not always regular.

Later, yeast artificial chromosome (YAC) clones were incorporated to bridge the gaps between cosmid contigs and provided coverage of regions that were not represented in the cosmid libraries. Alignment of the existing genetic and physical maps into the C. elegans genome map was greatly facilitated through the cooperation of the entire “worm community”. After the physical map had been nearly completed, the effort to sequence the entire genome became both feasible and desirable. By that time, this attempt was significantly larger than any sequencing project before and was nearly two orders of magnitude more expensive than the mapping effort.

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