Download e-book for kindle: Bioinformatics and Functional Genomics by Jonathan Pevsner

By Jonathan Pevsner

The bestselling advent to bioinformatics and genomics – now in its 3rd edition

Widely acquired in its past variations, Bioinformatics and practical Genomics bargains the main broad-based creation to this explosive new self-discipline. Now in a completely up to date and elevated 3rd version, it remains to be the go-to resource for college students and execs serious about biomedical research.

This ebook presents up to the moment insurance of the fields of bioinformatics and genomics. good points new to this variation include:

  • Extensive revisions and a mild reorder of chapters for a better organization
  • A fresh bankruptcy on next-generation sequencing
  • An elevated better half web site, additionally up to date as and while new info turns into available
  • Greater emphasis on a computational method, with transparent assistance of the way software program instruments paintings and introductions to using command-line instruments reminiscent of software program for next-generation series research, the R programming language, and NCBI seek utilities

The publication is complemented by way of lavish illustrations and greater than 500 figures and tables - many newly-created for the 3rd variation to augment readability and knowing. every one bankruptcy contains studying targets, an issue set, pitfalls part, containers explaining key concepts and mathematics/statistics ideas, a precis, instructed studying, and a listing of freely on hand software program. Readers may possibly stopover at a similar web content for supplemental details equivalent to PowerPoints and audiovisual documents of lectures, and videocasts of ways to accomplish many uncomplicated operations: www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and useful Genomics, 3rd variation serves as a superb single-source textbook for complex undergraduate and starting graduate-level classes within the organic sciences and desktop sciences. it's also an integral source for biologists in a huge number of disciplines who use the instruments of bioinformatics and genomics to review specific examine difficulties; bioinformaticists and laptop scientists who strengthen laptop algorithms and databases; and clinical researchers and clinicians who are looking to comprehend the genomic foundation of viral, bacterial, parasitic, or different diseases.

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Extra info for Bioinformatics and Functional Genomics

Example text

Further documenting the specific steps you use allows others to independently repeat your analyses. In an effort to share software, many researchers use repositories such as GitHub. 6 Tool users and tool makers. The term “informatics” has been applied to an increasing number of disciplines in recent years including bioinformatics, public health informatics, medical informatics, and library informatics. Each of these disciplines is concerned with systematizing and analyzing increasingly large datasets.

Kennedy Krieger Institute sees 22,000 patients a year, mostly children with neurodevelopmental disorders from common conditions (such as autism spectrum disorder and intellectual disability) to rare genetic diseases. I am motivated to try to apply the tools of bioinformatics and genomics to help these children. This perspective has guided my writing of this book, which emphasizes the relevance of all the topics in bioinformatics and genomics to human disease in general. We are hopeful that genomics will lead to an understanding of the molecular bases of so many devastating conditions, and this in turn may one day lead to better diagnosis, prevention, treatment, and perhaps even cures.

The scope of bioinformatics includes all of life on Earth, including the three major branches of bacteria, archaea, and eukaryotes. Viruses, which exist on the borderline of the definition of life, are not depicted here. For all species, the collection and analysis of molecular sequence data allow us to describe the complete collection of DNA that comprises each organism (the genome). We can further learn the variations that occur between species and among members of a species, and we can deduce the evolutionary history of life on Earth.

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