Aspects of Slow and Persistent Virus Infections: Proceedings - download pdf or read online

By C. A. Mims (auth.), D. A. J. Tyrrell (eds.)

This ebook files the papers and discussions at a piece­ store which came about in London at the fifth and sixth of April 1979, as a part of the programme of the fee of the eu groups on clinical and Public wellbeing and fitness learn. but the perspectives expressed are these of the contributors involved and never of the EEC or any of its organs. the item was once to debate convinced organic points of common and experimental sluggish virus infections. as the quantity of information and the point of interest of curiosity various in recognize of every an infection the method and emphasis various additionally. in terms of scrapie, we mentioned the character of the agent and the mode of pathogenesis, when it comes to SSPE, the hunt for strange beneficial properties of the virus, and up to date aspect­ ed paintings at the immunology of the sickness. As for Visna we reviewed the current knowing of the virus and its pathogenicity and in addition box epidemiology and techniques for its regulate. there have been additionally basic papers, on interferon and oncornaviruses for instance. We thank all those that made the assembly attainable and enabled us to provide this e-book quick, in order that those that couldn't attend the assembly could however manage to learn loads of what went on at it. specifically we'd thank the Ciba origin who allowed us using their premises and Mrs. Jean Ashley who handled many of the arrangements.

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Additional resources for Aspects of Slow and Persistent Virus Infections: Proceedings of the European Workshop sponsored by the Commission of the European Communities on the advice of the Committee on Medical and Public Health Research, held in London(U.K.), April 5–6, 1979

Sample text

First, pretreatment of mice with normal hamster brain decreased the proportion of scrapie cases and increased incubation times following infection with hamster passaged scrapie agent (52). In the second study, mouse passaged ME7 agent was transmitted to sheep and then reisolated in mice. On reisolation, the incubation period of ME7 was extended at first passage in mice relative to the second but the increase was exactly in accord with the lower estimated titre in mice of the sheep passaged agent (53,54) .

In one study it was found that the early passages of a source of scrapie agent in hamsters were associated with the loss of strain 431K which had a longer incubation period than strain 263K (55). In the third process a prolonged 'zero-phase' occurs at first passage which is either absent or much reduced on second passage in the new host (56). 9). In one study of the transmission of hamster scrapie to mice it was found that the dynamics of agent replication in brain at first and second passage were almost identical so that the difference in incubation periods was entirely accounted for by a prolonged zero-phase at first passage (56).

P . injection of weanl ing mi ce . The bands indicate ranges over which the dynamics can be controlled with different agents and hosts . Survival is redu ced by the nec e ssary e xp e di e ncy of sacrificing a proportion of animals prior to natural death , and this band is therefore not a " l ifespan c urve". The entire sequence of events is co mp l eted we ll before median life span . :\tm - survival curve . c. p. titre ; injectio~ 35 In contrast, much more prolong e d incubation periods follow the use of slow agent combinations (such as 22A in Sinc s ?

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