New PDF release: Applying genomic and proteomic microarray technology in drug

By Robert S. Matson

Microarrays play an more and more major function in drug discovery. the economic panorama has replaced dramatically over the last few years and researchers have made nice developments in regards to building and use. Now in its moment variation, utilising Genomic and Proteomic Microarray know-how in Drug Discovery highlights, describes, and evaluates present clinical study utilizing microarray know-how in Read more...

summary: Microarrays play an more and more major position in drug discovery. the industrial panorama has replaced dramatically over the last few years and researchers have made nice developments in regards to building and use. Now in its moment variation, employing Genomic and Proteomic Microarray know-how in Drug Discovery highlights, describes, and evaluates present clinical learn utilizing microarray expertise in genomic and proteomic functions. up-to-date and revised to mirror contemporary development within the box, the second one version discusses: multiplied omics-driven purposes, together with the parts

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The authors conclude that “probes that contain G-stacks perform poorly on microarrays, because G-stacks tend to increase cross hybridization and reduce target-specific hybridization” (p. 2571). McCall et al. (2011) examined the quality of GeneChip microarrays across more than 22,000 HGU133 arrays from data held in the Gene Expression Omnibus database. They observed that about 12% of the GeneChip HUG133a arrays reported were of poor quality. The study concluded that the most likely source of the quality issue is attributed to the array chip itself.

J. Immunol. Methods 250: 81–91, 2001. Carroll GT, Wang D, Turro NJ, Koberstein JT. Photochemical micropatterning of carbohydrates on a surface. Langmuir 22: 2899–2905, 2006. Clarke PA, te Poele R, Wooster R, Workman P. Gene expression microarray analysis in cancer biology, pharmacology, and drug development: Progress and potential. Biochem. Pharmacol. 62: 1311–1336, 2001. Copeland S, Siddiqui J, Remick D. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.

5 million features on each array. In order to commercialize the in situ array, Affymetrix needed access to certain intellectual properties, especially the Southern Array patents (see WO89/10977 patent family, Oxford Gene Technologies [OGT]). Affymetrix obtained license through a business relationship with Beckman Coulter that originally held the first and exclusive Southern license. Later, the company relinquished their exclusivity. Beckman Coulter and Affymetrix subsequently entered into an Array Automation, LLC, to automate the processing of Affymetrix chips.

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