By Aidong Zhang
This e-book is especially good written, in nice element and readability. The identify "Advanced" sounds formidable to a few intermediate or access point statisticians, however the math information within the ebook is particularly comprehensible, provided as beneficial aid for you to comprehend the defined statistical equipment.
I might hugely suggest this e-book to statisticians with all statistical backgrounds who're new to the world of microarray info research. This e-book is ideal as a textbook for a primary process microarray information research too.
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Extra info for Advanced analysis of gene expression microarray data
3 Image Scanning After the completion of hybridization, the surface of the hybridized array is scanned to produce a microarray image. As previously mentioned, samples are labeled with biotin or fluorescent dyes t h a t emit detectable light when stimulated by a laser. T h e emitted light is captured by the photo-multiplier t u b e ( P M T ) in a scanner, and the intensity is recorded. Most scanners contain one or more lasers t h a t are focused onto the array (for two-channel microarrays, the scanner uses two lasers) .
Genotype refers to the genetic makeup of an individual, while the outward characteristics of the individual are its phenotype. They are, naturally, connected, as the phenotype is shaped, develops, and functions on the basis of the information provided by and encoded in the genotype . The recent development of microarray technology, which is the focus of this book, has proved to be a useful tool to help delineate the genotype-phenotype relationship . 7 Summary This chapter has provided a brief introduction to the salient characteristics of cells, proteins, DNA, RNA, and other biological concepts which will underlie the discussions in subsequent chapters.
A molecule of water is lost (condensation) as each linkage forms. - N — @—C-^-N- © - C N terminus (*H3N) Data i JL B Peptide linkage H H Microarray on B C terminus (COO - ) Repetition of this reaction links many amino acids together into a polypeptides. Fig. 4 Formation of a peptide bond between two amino acids by the dehydration of the amino end of one amino acid and the acid end of the other amino acid (Figure is from  with permission from Sinaucr Associates). result of secondary-structure packing on a more global level, such as bonding or repulsion between R-groups.